Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 10/20 | 0.66 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.66 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1757759 | 0.86 | CYP11B1 (0.66) | CYP11B1CYP11B2IDO1ALDH1A1PKM | |
| SCHEMBL1758083 | 0.85 | CYP11B1 (0.68) | CYP11B1CYP11B2IDO1ALDH1A1PKM | |
| SCHEMBL7696780 | 0.83 | CYP11B1 (0.67) | CYP11B1CYP11B2IDO1ALDH1A1CYP19A1 | |
| SCHEMBL7700254 | 0.83 | CYP11B1 (0.67) | CYP11B1CYP11B2IDO1ALDH1A1PKM | |
| SCHEMBL8140959 | 0.83 | CYP11B1 (0.67) | CYP11B1CYP11B2IDO1ALDH1A1CYP19A1 | |
| SCHEMBL765399 | 0.83 | CYP11B1 (0.67) | CYP11B1CYP11B2IDO1ALDH1A1PKM | |
| SCHEMBL7986619 | 0.83 | CYP11B1 (0.67) | CYP11B1CYP11B2IDO1CYP19A1 | |
| SCHEMBL8134371 | 0.83 | CYP11B1 (0.62) | CYP11B1CYP11B2IDO1ALDH1A1KDM4E | |
| SCHEMBL8135755 | 0.82 | CYP11B1 (0.65) | CYP11B1CYP11B2IDO1ALDH1A1KDM4C | |
| SCHEMBL5935193 | 0.81 | CYP11B1 (0.63) | CYP11B1CYP11B2IDO1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002057258-A1 | CYCLO`D!AZEPANE DERIVATIVES WHICH ARE USED AS FARNESYLTRANSFERASE INHIBITORS AND METHOD FOR THE PREPARATION THEREOF | LES LABORATOIRES SERVIER (FR) | 2002-07-25 | — | — | WO | disclosed |
| WO-2002057257-A1 | CYCLO`C!AZEPANE DERIVATIVES WHICH ARE USED AS FARNESYLTRANSFERASE INHIBITORS AND METHOD FOR THE PREPARATION THEREFOR | LES LABORATOIRES SERVIER (FR) | 2002-07-25 | — | — | WO | disclosed |
| EP-1054882-A1 | CONDENSED HETEROCYCLIC SYSTEM DERIVATIVES, PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041248-A1 | CONDENSED HETEROCYCLIC SYSTEM DERIVATIVES, PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AVENTIS PHARMA S.A. (FR) | 1999-08-19 | — | — | WO | disclosed |