Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 3/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL904136 | 0.87 | USP2 (0.49) | USP2SMN1; SMN2DDB1CRBNKDM4E | |
| SCHEMBL289578 | 0.87 | DDB1 (0.43) | USP2SMN1; SMN2DDB1CRBNKDM4E | |
| SCHEMBL21285082 | 0.86 | USP2 (0.47) | USP2SMN1; SMN2DDB1CRBNKDM4E | |
| SCHEMBL16862285 | 0.85 | DDB1 (0.43) | USP2SMN1; SMN2DDB1CRBNKDM4E | |
| SCHEMBL20669341 | 0.83 | DDB1 (0.41) | USP2SMN1; SMN2DDB1CRBNKDM4E | |
| SCHEMBL5857800 | 0.83 | USP2 (0.49) | USP2SMN1; SMN2DDB1CRBNKDM4E | |
| SCHEMBL22849833 | 0.83 | USP2 (0.47) | USP2SMN1; SMN2ACACBGPR119CYP11B2 | |
| SCHEMBL17121748 | 0.82 | KDM4E (0.41) | USP2SMN1; SMN2DDB1CRBNKDM4E | |
| SCHEMBL4267194 | 0.82 | CRBN (0.46) | USP2SMN1; SMN2DDB1CRBNKDM4E | |
| SCHEMBL19032234 | 0.81 | CYP11B2 (0.45) | USP2SMN1; SMN2DDB1CRBNACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071459-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | GLAXOSMITHKLINE LLC | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071459-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | MCHR1, MCHR2, MC1R | USP2 3173/4885SMN1; SMN2 4041/4885DDB1 3824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.