Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12410054 | 0.82 | TDP1 (0.56) | TDP1KDM4EPKMHTR3BHTR3A | |
| SCHEMBL7699018 | 0.75 | PDE10A (0.49) | TDP1KDM4EPKMHRH4L3MBTL1 | |
| Hydrochloric Acid SCHEMBL9989517 | 0.74 | PDE10A (0.48) | TDP1KDM4EPKMHRH4L3MBTL1 | |
| SCHEMBL31318337 | 0.70 | TDP1 (0.41) | TDP1KDM4EPKMHTR3BHTR3A | |
| SCHEMBL7701524 | 0.70 | PDE10A (0.57) | TDP1KDM4EPKML3MBTL1MAPT | |
| SCHEMBL7701760 | 0.70 | KDM4E (0.59) | TDP1KDM4EL3MBTL1MAPTNPSR1 | |
| SCHEMBL29451077 | 0.70 | TDP1 (1.00) | TDP1KDM4EPKMHTR3BHTR3A | |
| SCHEMBL116696 | 0.70 | TDP1 (1.00) | TDP1KDM4EPKMHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL9988047 | 0.69 | PDE10A (0.56) | TDP1KDM4EPKML3MBTL1MAPT | |
| Hydrochloric Acid SCHEMBL2593673 | 0.69 | KDM4E (0.57) | TDP1KDM4EL3MBTL1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011143365-A1 | NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |