Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2880966 | 0.98 | TAAR1 (0.50) | TAAR1ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL7198596 | 0.89 | TAAR1 (0.50) | TAAR1ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL2886265 | 0.87 | TAAR1 (0.52) | TAAR1ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL2886363 | 0.85 | TAAR1 (0.50) | TAAR1ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL2888284 | 0.84 | TAAR1 (0.48) | TAAR1ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL2886603 | 0.84 | TAAR1 (0.48) | TAAR1ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL2883324 | 0.84 | TAAR1 (0.48) | TAAR1ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL2886419 | 0.84 | TAAR1 (0.48) | TAAR1ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL2885625 | 0.84 | TAAR1 (0.48) | TAAR1ADRA2AADRA2BADRA2CSMN1; SMN2 | |
| SCHEMBL2886309 | 0.84 | TAAR1 (0.48) | TAAR1ADRA2AADRA2BADRA2CSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002083650-A1 | NOVEL SULFONYLAMINO-PYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2002-10-24 | — | — | WO | disclosed |