Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.71 |
| ▸ | MAPK13 | O15264 | 16/20 | 0.71 |
| ▸ | MAPK12 | P53778 | 16/20 | 0.71 |
| ▸ | MAPK11 | Q15759 | 16/20 | 0.71 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.54 |
| ▸ | RAF1 | P04049 | 3/20 | 0.54 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17938001 | 0.83 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL13819579 | 0.83 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7670440 | 0.80 | MAPK14 (0.88) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7670444 | 0.80 | MAPK14 (0.88) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7675742 | 0.77 | MAPK11 (0.56) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7699663 | 0.75 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7699660 | 0.75 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5754048 | 0.72 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6172619 | 0.70 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6172305 | 0.70 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350744-B1 | PYRMIDINE OR PYRIDINE DERIVATIVES; ANTIARTHRITIC AND ANTIINFLAMMATORY AGENTS; CACHEXIA TREATMENT; INTERLEUKIN AND TUMOR NECROSIS FACTOR INHIBITORS | MERCK & CO., INC. | 2002-02-26 | — | — | US | disclosed |