Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.42 |
| ▸ | REN | P00797 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PEPD | P12955 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL1537349 | 1.00 | ACE (0.42) | ACERENLMNAHSD17B10CYP2C19 | |
| SCHEMBL3262654 | 0.88 | ACE (0.44) | ACERENLMNAHSD17B10CYP2C19 | |
| SCHEMBL8089 | 0.88 | — | — | |
| SCHEMBL200241 | 0.88 | — | — | |
| SCHEMBL7411 | 0.88 | — | — | |
| Urea SCHEMBL2031932 | 0.86 | ACE (0.41) | ACERENLMNAHSD17B10CYP2C19 | |
| Hydrochloric Acid SCHEMBL11775905 | 0.86 | ACE (0.43) | ACERENLMNAHSD17B10CYP2C19 | |
| Methane SCHEMBL14937660 | 0.86 | ACE (0.43) | ACERENLMNAHSD17B10CYP2C19 | |
| Ammonia Solution, Strong SCHEMBL20920825 | 0.86 | ACE (0.43) | ACERENLMNAHSD17B10CYP2C19 | |
| SCHEMBL9312770 | 0.86 | ACE (0.43) | ACERENLMNAHSD17B10CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339185-B1 | Plant termination sequence | DREXEL UNIVERSITY | 2002-01-15 | — | — | US | disclosed |
| EP-0778727-A4 | A PLANT PROMOTER USEFUL FOR DIRECTING THE EXPRESSION OF FOREIGN PROTEINS TO THE PLANT EPIDERMIS | UNIV DREXEL (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5744334-A | TRANSFORMATION WITH PROMOTER-GENE CONSTRUCT | DREXEL UNIVERSITY (US) | 1998-04-28 | — | — | US | disclosed |
| US-5646333-A | GENETIC ENGINEERED POLYNUCLEOTIDES FOR PRODUCING ENZYME, ENZYME INHIBITOR, ENDOTOXIN | DREXEL UNIVERSITY (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0778727-A1 | A PLANT PROMOTER USEFUL FOR DIRECTING THE EXPRESSION OF FOREIGN PROTEINS TO THE PLANT EPIDERMIS | DREXEL UNIVERSITY (US) | 1997-06-18 | — | — | EP | disclosed |
| WO-1996007313-A1 | A PLANT PROMOTER USEFUL FOR DIRECTING THE EXPRESSION OF FOREIGN PROTEINS TO THE PLANT EPIDERMIS | DREXEL UNIVERSITY (US) | 1996-03-14 | — | — | WO | disclosed |