Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20183370 | 0.84 | CYP2D6 (0.47) | CYP2D6OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL20183371 | 0.84 | CYP2D6 (0.47) | CYP2D6OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL20183318 | 0.84 | CYP2D6 (0.47) | CYP2D6OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL20183317 | 0.84 | CYP2D6 (0.47) | CYP2D6OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL20183314 | 0.84 | CYP2D6 (0.47) | CYP2D6OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL8775479 | 0.79 | CYP2D6 (0.49) | CYP2D6OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL3187502 | 0.79 | CYP2D6 (0.49) | CYP2D6OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL13483618 | 0.79 | CYP2D6 (0.49) | CYP2D6OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL374064 | 0.79 | CYP2D6 (0.49) | CYP2D6OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL9057277 | 0.77 | EPHX2 (0.39) | CYP2D6OPRM1OPRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071459-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | GLAXOSMITHKLINE LLC | 2012-03-22 | — | — | US | disclosed |
| US-20120071459-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | GLAXOSMITHKLINE LLC | 2012-03-22 | — | — | US | disclosed |
| US-20120071459-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | GLAXOSMITHKLINE LLC | 2012-03-22 | — | — | US | disclosed |
| WO-2010141545-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2010-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071459-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | MCHR1, MCHR2, MC1R | CYP2D6 557/4885OPRM1 81/4885OPRL1 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.