Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374064 | 1.00 | CYP2D6 (0.49) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL3187502 | 0.81 | CYP2D6 (0.49) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL13483618 | 0.81 | CYP2D6 (0.49) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL769832 | 0.79 | CYP2D6 (0.46) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL9596277 | 0.78 | CYP2D6 (0.61) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL48088 | 0.78 | CYP2D6 (0.61) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL2916607 | 0.78 | CYP2D6 (0.61) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL4187954 | 0.78 | CYP2D6 (0.45) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL4182073 | 0.78 | CYP2D6 (0.45) | CYP2D6OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL8775418 | 0.76 | CHRM2 (0.46) | CYP2D6OPRL1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529688-B1 | Azaspiro(n,m)alkanes and diazaspiro(n,m)-alkanes | DAIICHI SEIYAKU CO (JP) | 1997-11-12 | — | — | EP | disclosed |
| US-5508428-A | Spiro compound | DAIICHI PHAMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| EP-0357047-B1 | Spiro compounds | DAIICHI SEIYAKU CO (JP) | 1993-11-03 | — | — | EP | disclosed |