Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.70 |
| ▸ | PIM1 | P11309 | 4/20 | 0.65 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.65 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7698700 | 1.00 | HPGD (0.70) | HPGDPIM1PIM2GPR35PTGS2 | |
| SCHEMBL7698704 | 1.00 | HPGD (0.70) | HPGDPIM1PIM2GPR35PTGS2 | |
| SCHEMBL7698701 | 1.00 | HPGD (0.70) | HPGDPIM1PIM2GPR35PTGS2 | |
| SCHEMBL7693214 | 0.90 | PIM1 (0.72) | HPGDPIM1PIM2GPR35PTGS2 | |
| SCHEMBL7693216 | 0.90 | PIM1 (0.72) | HPGDPIM1PIM2GPR35PTGS2 | |
| SCHEMBL7693218 | 0.90 | PIM1 (0.72) | HPGDPIM1PIM2GPR35PTGS2 | |
| SCHEMBL7694242 | 0.89 | HPGD (0.67) | HPGDPIM1PIM2GPR35PTGS2 | |
| SCHEMBL7694250 | 0.89 | HPGD (0.67) | HPGDPIM1PIM2GPR35PTGS2 | |
| SCHEMBL7694244 | 0.89 | HPGD (0.67) | HPGDPIM1PIM2GPR35PTGS2 | |
| SCHEMBL7694253 | 0.89 | HPGD (0.67) | HPGDPIM1PIM2GPR35PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002050024-A2 | THIAZOLIDINEDIONES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-06-27 | — | — | WO | claimed |
| WO-2002050024-A2 | THIAZOLIDINEDIONES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-06-27 | — | — | WO | disclosed |