Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9965281 | 0.86 | MAPT (0.44) | MAPTALDH1A1CYP2A6CYP11B1CYP11B2 | |
| SCHEMBL20609436 | 0.82 | CYP2A6 (0.55) | DHFRALDH1A1CYP2A6CRHR1CYP1A2 | |
| SCHEMBL12989388 | 0.81 | CYP11B1 (0.52) | ALDH1A1CYP2A6CYP11B1CYP11B2MEN1 | |
| SCHEMBL29801671 | 0.79 | CYP2A6 (0.62) | DHFRALDH1A1CYP2A6CYP1A2CYP3A4 | |
| SCHEMBL1132842 | 0.79 | CYP2A6 (0.62) | DHFRALDH1A1CYP2A6CYP1A2CYP3A4 | |
| SCHEMBL9965263 | 0.79 | MAPT (0.48) | MAPTALDH1A1CYP2A6MEN1KMT2A | |
| SCHEMBL1041432 | 0.76 | CYP1A2 (0.55) | MAPTCYP2A6CYP11B1CYP11B2MEN1 | |
| SCHEMBL28837734 | 0.76 | ALDH1A1 (0.56) | MAPTDHFRALDH1A1CYP2A6MEN1 | |
| SCHEMBL262434 | 0.76 | CYP2A6 (0.52) | DHFRALDH1A1CYP2A6MEN1KMT2A | |
| SCHEMBL29416646 | 0.76 | CYP2A6 (0.52) | DHFRALDH1A1CYP2A6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216285-A1 | FLUORESCENT MALEIMIDES AND USES THEREOF | Ciba SC Holding AG (CH) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001019939-A1 | FLUORESCENT MALEIMIDES AND USES THEREOF | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2001-03-22 | — | — | WO | disclosed |