Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | APP | P05067 | 4/20 | 0.38 |
| ▸ | SNCA | P37840 | 4/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873728 | 0.74 | MAPT (0.41) | RXFP1MAPTAPPSNCAGRM5 | |
| SCHEMBL5873726 | 0.74 | MAPT (0.41) | RXFP1MAPTAPPSNCAGRM5 | |
| SCHEMBL7704854 | 0.71 | CCNT1 (0.40) | MAPTAPPSNCAALDH1A1TP53 | |
| SCHEMBL5873898 | 0.70 | MAPT (0.40) | RXFP1MAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL5873903 | 0.70 | MAPT (0.40) | RXFP1MAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL7661382 | 0.69 | TRPV1 (0.44) | MAPTALDH1A1HSD17B10NPSR1KDM4E | |
| SCHEMBL19297675 | 0.67 | BRD4 (0.43) | THRBALDH1A1NPSR1BRD4GAA | |
| SCHEMBL6884688 | 0.65 | NTRK1 (0.45) | MAPT | |
| SCHEMBL5873722 | 0.65 | NTRK1 (0.45) | MAPT | |
| SCHEMBL8018899 | 0.65 | KMT2A (0.40) | MAPTTHRBALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350747-B1 | PROTEIN SERINE/THREONINE KINASE AND PROTEIN TYROSINE KINASE ENZYME INHIBITORS; ANGIOGENESIS INHIBITORS; ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | GLAXO WELLCOME INC. | 2002-02-26 | — | — | US | disclosed |