SCHEMBL7700302

SCHEMBL7700302

O=C(C=Cc1ccc(Cl)c(Cl)c1)N1CCC(CN2CCC(c3c[nH]c4cc(C(F)(F)F)ccc34)CC2)CC1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 1/20 0.66
CCR2 P41597 19/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7702549 0.87 SLC2A1 (0.82) SLC2A1CCR2
SCHEMBL7703004 0.84 CCR2 (0.76) SLC2A1CCR2
SCHEMBL7700299 0.81 CCR2 (0.49) SLC2A1CCR2
SCHEMBL18840986 0.75 CCR2 (1.00) SLC2A1CCR2
SCHEMBL7697550 0.75 CCR2 (0.75) SLC2A1CCR2
SCHEMBL5352891 0.75 CCR2 (0.75) SLC2A1CCR2
SCHEMBL14387004 0.75 CCR2 (0.75) SLC2A1CCR2
SCHEMBL5360802 0.74 CCR2 (0.78) SLC2A1CCR2
SCHEMBL5360806 0.74 CCR2 (0.78) SLC2A1CCR2
SCHEMBL7695532 0.74 CCR2 (0.68) SLC2A1CCR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002079190-A1 3-SUBSTITUTED INDOLES AS CHEMOKINE ANTAGONISTS SMITHKLINE BEECHAM P.L.C. (GB) 2002-10-10 WO disclosed