Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.86 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14947100 | 0.93 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL7700632 | 0.89 | PDE4A (0.86) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL4565777 | 0.88 | PDE4A (0.78) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL7698552 | 0.83 | PDE4A (0.70) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL14947099 | 0.82 | PDE4A (0.71) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL14935906 | 0.81 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL30869220 | 0.81 | PDE4A (0.81) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL7702419 | 0.81 | PDE4A (0.81) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| Orismilast SCHEMBL14947097 | 0.80 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| Orismilast SCHEMBL29525290 | 0.80 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011160632-A1 | BENZODIOXOLE OR BENZODIOXEPINE HETEROCYCLIC COMPOUNDS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-12-29 | — | — | WO | disclosed |