Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.66 |
| ▸ | HPGD | P15428 | 5/20 | 0.66 |
| ▸ | GLA | P06280 | 5/20 | 0.66 |
| ▸ | GAA | P10253 | 5/20 | 0.66 |
| ▸ | CA9 | Q16790 | 5/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.66 |
| ▸ | CA12 | O43570 | 4/20 | 0.66 |
| ▸ | CA1 | P00915 | 4/20 | 0.66 |
| ▸ | CASP1 | P29466 | 2/20 | 0.66 |
| ▸ | CASP7 | P55210 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspartic Acid SCHEMBL7700642 | 1.00 | ALDH1A1 (0.66) | ALDH1A1KDM4EHPGDGLAGAA | |
| Asparagine SCHEMBL27896279 | 0.92 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDGLAGAA | |
| Asparagine SCHEMBL4176738 | 0.92 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDGLAGAA | |
| Leucine SCHEMBL19695473 | 0.89 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDGLAGAA | |
| Leucine SCHEMBL27779804 | 0.89 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDGLAGAA | |
| Leucine SCHEMBL1776947 | 0.89 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDGLAGAA | |
| Serine SCHEMBL6428011 | 0.89 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDGLAGAA | |
| Serine SCHEMBL27896307 | 0.89 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDGLAGAA | |
| Leucine SCHEMBL4185791 | 0.88 | ALDH1A1 (0.63) | ALDH1A1KDM4EHPGDGLAGAA | |
| Leucine SCHEMBL22611961 | 0.88 | ALDH1A1 (0.63) | ALDH1A1KDM4EHPGDGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102994387-A | High throughput screening method of aminopeptidase and high-yield strain thereof | TIANJIN INST IND BIOTECHNOLOGY | 2013-03-27 | — | — | CN | claimed |
| CN-105288619-A | Non-invasive systems and methods for in-situ photobiomodulation | UNIV DUKE | 2016-02-03 | — | — | CN | disclosed |
| CN-102056625-B | Non-invasive system and method for in situ photobiomodulation | IMMUNOLIGHT, LLC (US) | 2015-11-25 | — | — | CN | disclosed |
| CN-102994387-A | High throughput screening method of aminopeptidase and high-yield strain thereof | TIANJIN INST IND BIOTECHNOLOGY | 2013-03-27 | — | — | CN | disclosed |
| US-6348570-B1 | TETRAPEPTIDES; DIAGNOSING AND MONITORING INFLAMMATORY, NERVOUS SYSTEM, SKIN, CARDIOVASCULAR, RESPIRATORY SYSTEM, GASTROINTESTINAL, UROGENITAL AND IMMUNE DISORDERS; EVALUATING INHIBITORS | MERCK & CO., INC. | 2002-02-19 | — | — | US | disclosed |