Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7700794 | 1.00 | ALOX15 (0.50) | ALOX15MAPTALDH1A1USP2HCAR2 | |
| SCHEMBL14143123 | 1.00 | ALOX15 (0.50) | ALOX15MAPTALDH1A1USP2HCAR2 | |
| SCHEMBL7700791 | 1.00 | ALOX15 (0.50) | ALOX15MAPTALDH1A1USP2HCAR2 | |
| SCHEMBL11752925 | 0.89 | ALOX15 (0.46) | ALOX15MAPTALDH1A1USP2HCAR2 | |
| SCHEMBL11752919 | 0.89 | ALOX15 (0.46) | ALOX15MAPTALDH1A1USP2HCAR2 | |
| SCHEMBL9618072 | 0.84 | ALOX15 (0.49) | ALOX15ALDH1A1USP2HCAR2TSHR | |
| SCHEMBL9618071 | 0.84 | ALOX15 (0.49) | ALOX15ALDH1A1USP2HCAR2TSHR | |
| SCHEMBL8347186 | 0.84 | ALOX15 (0.49) | ALOX15ALDH1A1USP2HCAR2TSHR | |
| SCHEMBL4195956 | 0.82 | MAPT (0.46) | MAPTALDH1A1HCAR2TSHRLMNA | |
| SCHEMBL4199147 | 0.82 | MAPT (0.46) | MAPTALDH1A1HCAR2TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983221-B1 | CYCLOHEXANEDIOL DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-04-03 | — | — | EP | disclosed |
| EP-0983221-A1 | CYCLOHEXANEDIOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-08 | — | — | EP | disclosed |
| US-5969190-A | TREATING HYPERPROLIFERATIVE SKIN DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1998052894-A1 | CYCLOHEXANEDIOL DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1998-11-26 | — | — | WO | disclosed |