Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 10/20 | 0.66 |
| ▸ | LMNA | P02545 | 5/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.66 |
| ▸ | SCN1A | P35498 | 2/20 | 0.66 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.66 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.66 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.66 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.66 |
| ▸ | GBA1 | P04062 | 1/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.66 |
| ▸ | HTR2A | P28223 | 1/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.66 |
| ▸ | HTR2B | P41595 | 1/20 | 0.66 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701472 | 1.00 | SCN4A (0.66) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL7701144 | 1.00 | SCN4A (0.66) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL11329870 | 0.87 | SCN4A (0.51) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL10636052 | 0.87 | SCN4A (0.56) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL5607510 | 0.85 | TSHR (0.73) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL15241352 | 0.83 | SCN4A (0.78) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL8238232 | 0.83 | SCN4A (0.70) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL14509238 | 0.82 | SCN5A (0.54) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL23598063 | 0.80 | TSHR (0.67) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL11464779 | 0.80 | TSHR (0.67) | SCN4ALMNACYP2D6SCN1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3200749-A | — | — | None | — | — | JP | disclosed |
| US-20190270696-A1 | COMPOUNDS AS INHIBITORS OF SODIUM CHANNELS | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2019-09-05 | — | — | US | disclosed |
| CN-102603543-B | Preparation method of mexiletine hydrochloride | FOSHAN PRIZEN MEDICAL TECHNOLOGY CO LTD | 2014-07-02 | — | — | CN | disclosed |
| CN-101529011-B | Method for the treatment of substrates | BASF SE | 2012-12-12 | — | — | CN | disclosed |
| CN-102603543-A | Preparation method of mexiletine hydrochloride | FOSHAN PRIZEN MEDICAL TECHNOLOGY CO LTD | 2012-07-25 | — | — | CN | disclosed |
| CN-101529011-A | Method for the treatment of substrates | BASF SE (DE) | 2009-09-09 | — | — | CN | disclosed |
| EP-1037871-B1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | GYOGYSZERKUTATO INTEZET (HU) | 2002-07-03 | — | — | EP | disclosed |
| US-6265445-B1 | CARDIOVASCULAR DISORDERS | GYOGYSZERKUTATO INTEZET KFT (HU) | 2001-07-24 | — | — | US | disclosed |
| EP-1037871-A1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999029655-A1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | Gyógyszerkutató Intézet Kft. (HU) | 1999-06-17 | — | — | WO | disclosed |
| US-5420352-A | Reaction of alcohol with ammonia to form amine in a solvent in the presence of copper chromium catalyst and hydrogen | IDEMITSU KOSAN CO., LTD. (JP) | 1995-05-30 | — | — | US | disclosed |
| EP-0492615-B1 | Process for producing biguanide derivative | IDEMITSU KOSAN CO (JP) | 1995-03-08 | — | — | EP | disclosed |
| EP-0619294-A1 | PROCESS FOR PRODUCING 1-PHENOXY-2-AMINOPROPANE | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1994-10-12 | — | — | EP | disclosed |
| US-5286905-A | Heating hydrogen halide salt of phenoxyalkylamine with dicyandiamide in paraffinic hydrocarbon solvent | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1994-02-15 | — | — | US | disclosed |
| EP-0492615-A1 | Process for producing biguanide derivative | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1992-07-01 | — | — | EP | disclosed |
| JP-H03200749-A | PRODUCTION OF PHENOXYPROPYLAMINE | MITSUI TOATSU CHEM INC | 1991-09-02 | — | — | JP | disclosed |
| US-4082808-A | ANTIOXIDANTS, INTERMEDIATES FOR POLYESTERS, POLYCARBONATES, EPOXY RESINS | GENERAL ELECTRIC COMPANY (US) | 1978-04-04 | — | — | US | disclosed |
| US-4064158-A | Process for the preparation of an organomercaptophenol from sulfur, a 2,6-disubstituted phenol, and an activated olefin or an epoxy compound | GENERAL ELECTRIC COMPANY (US) | 1977-12-20 | — | — | US | disclosed |
| US-3979460-A | ANTIOXIDANTS | GENERAL ELECTRIC COMPANY (US) | 1976-09-07 | — | — | US | disclosed |
| US-3953519-A | BASES, EPOXY COMPOUNDS, OLEFINS | GENERAL ELECTRIC COMPANY (US) | 1976-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190270696-A1 | COMPOUNDS AS INHIBITORS OF SODIUM CHANNELS | SCN1B, CACNA1E, SCN2B | SCN4A 48/4885LMNA 1789/4885CYP2D6 2298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.