Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 10/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.70 |
| ▸ | SCN1A | P35498 | 2/20 | 0.70 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.70 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.70 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.70 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.70 |
| ▸ | GBA1 | P04062 | 1/20 | 0.70 |
| ▸ | MAOA | P21397 | 1/20 | 0.70 |
| ▸ | HTR2A | P28223 | 1/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.70 |
| ▸ | HTR2B | P41595 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15241352 | 0.86 | SCN4A (0.78) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL16473759 | 0.86 | SCN4A (0.55) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL29707444 | 0.86 | SCN4A (0.52) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL16479209 | 0.85 | SCN4A (0.53) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL12902764 | 0.83 | SCN4A (0.51) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL23079027 | 0.83 | SCN4A (0.66) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL7701472 | 0.83 | SCN4A (0.66) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL10256513 | 0.83 | SCN4A (0.66) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL7245918 | 0.83 | SCN4A (0.66) | SCN4ALMNACYP2D6SCN1ASCN5A | |
| SCHEMBL7701144 | 0.83 | SCN4A (0.66) | SCN4ALMNACYP2D6SCN1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11673855-B2 | Voltage gated sodium channel imaging agents | THE GENERAL HOSPITAL CORPORATION (US) | 2023-06-13 | — | — | US | disclosed |
| US-11529343-B2 | Compositions and methods for identifying and treating dystonia disorders | DUKE UNIVERSITY (US) | 2022-12-20 | — | — | US | disclosed |
| US-20210069175-A1 | Compositions and Methods for Identifying and Treating Dystonia Disorders | DUKE UNIVERSITY (US) | 2021-03-11 | — | — | US | disclosed |
| CN-101578344-B | Adhesive composition for optical waveguide, adhesive film for optical waveguide and adhesive sheet for optical waveguide using same, and optical device using same | HITACHI CHEMICAL CO LTD | 2013-07-10 | — | — | CN | disclosed |
| US-20120196933-A1 | MEXILETINE PRODRUGS | FRANKLIN RICHARD (GB) | 2012-08-02 | — | — | US | disclosed |
| US-20110178092-A1 | HIV-1 Protease Inhibitors | UNIVERSITY OF MARYLAND, COLLEGE PARK | 2011-07-21 | — | — | US | disclosed |
| US-20110178092-A1 | HIV-1 Protease Inhibitors | UNIVERSITY OF MARYLAND, COLLEGE PARK | 2011-07-21 | — | — | US | disclosed |
| US-7838533-B2 | Azaindole inhibitors of MTP and ApoB | MERCK PATENT GMBH (DE) | 2010-11-23 | — | — | US | disclosed |
| US-7649015-B2 | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2010-01-19 | — | — | US | disclosed |
| CN-101578344-A | Adhesive composition for optical waveguide, adhesive film for optical waveguide and adhesive sheet for optical waveguide using same, and optical device using same | HITACHI CHEMICAL CO LTD (JP) | 2009-11-11 | — | — | CN | disclosed |
| US-20090036481-A1 | Novel Azaindole Inhibitors of Mtp and Apob | MERCK PATENT GMBH (DE) | 2009-02-05 | — | — | US | disclosed |
| EP-1771446-B1 | AZAINDOLE INHIBITORS OF MTP AND APOB | MERCK PATENT GMBH (DE) | 2008-06-11 | — | — | EP | disclosed |
| US-20070190523-A1 | Method and compositions for identifying anti-hiv therapeutic compounds | GILEAD SCIENCES, INC. | 2007-08-16 | — | — | US | disclosed |
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | GILEAD SCIENCES, INC. | 2007-01-11 | — | — | US | disclosed |
| WO-2007002172-A2 | HIV-1 PROTEASE INHIBITORS | UNIVERSITY OF MASSACHUSETTS (US) | 2007-01-04 | — | — | WO | disclosed |
| WO-2007002173-A1 | HIV-1 PROTEASE INHIBITORS, AND METHODS OF MAKING AND USING THEM | UNIVERSITY OF MASSACHUSETTS (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036481-A1 | Novel Azaindole Inhibitors of Mtp and Apob | APOB, MTPN, HDLBP | SCN4A 4389/4885LMNA 1279/4885CYP2D6 1163/4885 |
| US-20110178092-A1 | HIV-1 Protease Inhibitors | SERPINB1, PRSS1, TMPRSS4 | SCN4A 4565/4885LMNA 2776/4885CYP2D6 3685/4885 |
| US-20120196933-A1 | MEXILETINE PRODRUGS | SLC16A1, MTPN, SLC16A3 | SCN4A 88/4885LMNA 311/4885CYP2D6 63/4885 |
| US-11529343-B2 | Compositions and methods for identifying and treating dystonia disorders | DDHD2, SMN1; SMN2, MYO3B | SCN4A 635/4885LMNA 2037/4885CYP2D6 2981/4885 |
| US-11673855-B2 | Voltage gated sodium channel imaging agents | CACNA1B, CACNA1G, CACNA1I | SCN4A 73/4885LMNA 959/4885CYP2D6 3837/4885 |
| US-20210069175-A1 | Compositions and Methods for Identifying and Treating Dystonia Disorders | DDHD2, SMN1; SMN2, MYO3B | SCN4A 635/4885LMNA 2037/4885CYP2D6 2981/4885 |
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | PPA1, PNP, PPME1 | SCN4A 4308/4885LMNA 2720/4885CYP2D6 4036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.