Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SCN1A | P35498 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7698432 | 1.00 | KCNH2 (0.47) | KCNH2SIGMAR1PKMSCN4ALMNA | |
| SCHEMBL7698428 | 1.00 | KCNH2 (0.47) | KCNH2SIGMAR1PKMSCN4ALMNA | |
| Hydrochloric Acid SCHEMBL7701713 | 0.99 | KCNH2 (0.46) | KCNH2SIGMAR1PKMSCN4ALMNA | |
| SCHEMBL7699391 | 0.87 | KCNH2 (0.46) | KCNH2SIGMAR1PKMCDC25C | |
| Hydrochloric Acid SCHEMBL7697786 | 0.86 | KCNH2 (0.46) | KCNH2SIGMAR1PKMCDC25C | |
| SCHEMBL9628334 | 0.84 | KCNH2 (0.62) | KCNH2SIGMAR1 | |
| SCHEMBL7695487 | 0.82 | SCN4A (0.48) | KCNH2SIGMAR1SCN4ALMNASCN1A | |
| SCHEMBL7697606 | 0.82 | SCN4A (0.48) | KCNH2SIGMAR1SCN4ALMNASCN1A | |
| SCHEMBL7695490 | 0.82 | SCN4A (0.48) | KCNH2SIGMAR1SCN4ALMNASCN1A | |
| SCHEMBL7705321 | 0.80 | KCNH2 (0.70) | KCNH2SIGMAR1PKMCDC25C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037871-B1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | GYOGYSZERKUTATO INTEZET (HU) | 2002-07-03 | — | — | EP | disclosed |
| US-6265445-B1 | CARDIOVASCULAR DISORDERS | GYOGYSZERKUTATO INTEZET KFT (HU) | 2001-07-24 | — | — | US | disclosed |
| EP-1037871-A1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999029655-A1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | Gyógyszerkutató Intézet Kft. (HU) | 1999-06-17 | — | — | WO | disclosed |