Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701167 | 0.84 | KCNH2 (0.47) | KCNH2SIGMAR1 | |
| SCHEMBL7698428 | 0.84 | KCNH2 (0.47) | KCNH2SIGMAR1 | |
| SCHEMBL7698432 | 0.84 | KCNH2 (0.47) | KCNH2SIGMAR1 | |
| SCHEMBL7699391 | 0.83 | KCNH2 (0.46) | KCNH2ALDH1A1MAPTSIGMAR1 | |
| Hydrochloric Acid SCHEMBL7701713 | 0.83 | KCNH2 (0.46) | KCNH2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7697786 | 0.82 | KCNH2 (0.46) | KCNH2ALDH1A1MAPTSIGMAR1 | |
| SCHEMBL6182355 | 0.82 | GAA (0.57) | KCNH2ALDH1A1GAAMAPT | |
| SCHEMBL6182354 | 0.82 | GAA (0.57) | KCNH2ALDH1A1GAAMAPT | |
| SCHEMBL3929250 | 0.77 | KCNH2 (1.00) | KCNH2GAASIGMAR1 | |
| SCHEMBL10643494 | 0.75 | GAA (0.58) | KCNH2ALDH1A1GAAMAPTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245997-B1 | N-SUBSTITUTED P-AMINOETHYLSULPHON ANILIDES AS ANTIARRHYTHMIC AGENTS, AND INTERMEDIATES THEREFOR | Pfizer Limited (GB) | 1992-04-15 | — | — | EP | disclosed |
| US-5079248-A | Antifibrillatory agents; side effect reduction | PFIZER INC. (US) | 1992-01-07 | — | — | US | disclosed |
| US-4959366-A | Anti-arrhythmic agents | PFIZER INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0245997-A2 | N-substituted p-aminoethylsulphon anilides as antiarrhythmic agents, and intermediates therefor | Pfizer Limited (GB) | 1987-11-19 | — | — | EP | disclosed |