SCHEMBL7701244

SCHEMBL7701244

[CH2]OCc1ccccc1C(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.41
ALDH1A1 P00352 4/20 0.40
TDP1 Q9NUW8 2/20 0.40
TSHR P16473 1/20 0.40
CA2 P00918 1/20 0.37
RXRA P19793 1/20 0.35
RXRB P28702 1/20 0.35
RXRG P48443 1/20 0.35
MAOB P27338 2/20 0.34
ATM Q13315 2/20 0.34
NISCH Q9Y2I1 1/20 0.34
MAOA P21397 1/20 0.34
GAA P10253 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C19 P33261 1/20 0.33
HSD17B10 Q99714 1/20 0.33
POLB P06746 1/20 0.33
THRB P10828 1/20 0.33
ALOX12 P18054 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3685038 0.83 IDO1 (0.44) IDO1ALDH1A1TDP1TSHRCA2
SCHEMBL28893744 0.83 IDO1 (0.44) IDO1ALDH1A1TDP1TSHRCA2
SCHEMBL7803325 0.81 IDO1 (0.42) IDO1ALDH1A1TDP1TSHRCA2
SCHEMBL705888 0.79 IDO1 (0.41) IDO1ALDH1A1TDP1TSHRCA2
SCHEMBL514612 0.79 IDO1 (0.66) IDO1ALDH1A1TDP1MAOBATM
SCHEMBL13050671 0.79 ALDH1A1 (0.45) IDO1ALDH1A1TDP1TSHRCA2
SCHEMBL12597814 0.78 IDO1 (0.40) IDO1ALDH1A1TDP1TSHRCA2
SCHEMBL12894334 0.78 IDO1 (0.40) IDO1ALDH1A1TDP1TSHRCA2
SCHEMBL23759235 0.76 IDO1 (0.47) IDO1ALDH1A1TDP1TSHRCA2
SCHEMBL12894330 0.76 MAOB (0.49) RXRARXRBRXRGMAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6342501-B1 VIRICIDES THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2002-01-29 US disclosed
WO-2000042043-A1 PYRROLO[2,3-d]PYRIMIDINES AS ANTIVIRAL AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2000-07-20 WO disclosed
EP-0746559-A1 PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES AS ANTIVIRALS The Regents of The University of Michigan (US) 1996-12-11 EP disclosed
US-5543413-A VIRAL ACTIVITY AGAINST HUMAN CYTOMEGALOVIRUS AND HERPES SIMPLEX VIRUS REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1996-08-06 US disclosed
WO-1995023151-A1 PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES AS ANTIVIRALS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1995-08-31 WO disclosed