Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11033001 | 0.81 | ALDH1A1 (0.80) | ALDH1A1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL1340893 | 0.81 | ALDH1A1 (0.80) | ALDH1A1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL4111651 | 0.81 | HPGD (0.60) | ALDH1A1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL18613017 | 0.80 | ALDH1A1 (0.78) | ALDH1A1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL3158662 | 0.80 | ALDH1A1 (0.78) | ALDH1A1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL10522426 | 0.80 | ALDH1A1 (0.77) | ALDH1A1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL3150556 | 0.78 | ALDH1A1 (0.75) | ALDH1A1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL1135643 | 0.78 | ALDH1A1 (0.74) | ALDH1A1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL30042504 | 0.78 | ALDH1A1 (0.74) | ALDH1A1KMT2ANPC1MEN1RAB9A | |
| SCHEMBL2563520 | 0.76 | ALDH1A1 (0.60) | ALDH1A1KMT2AMEN1MAPTGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892804-B1 | ISOXAZOLIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2002-08-28 | — | — | EP | disclosed |
| US-6156747-A | Isoxazolidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-12-05 | — | — | US | disclosed |
| EP-0892804-A1 | ISOXAZOLIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997039001-A1 | ISOXAZOLIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-10-23 | — | — | WO | disclosed |