Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090562 | 0.93 | KDR (0.60) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7090565 | 0.92 | KDR (0.59) | KDRCHEK1CDK1CDK2KCNH2 | |
| SCHEMBL7162844 | 0.91 | CHEK1 (0.63) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7700688 | 0.91 | KDR (0.58) | KDRCHEK1CDK1CDK2KCNH2 | |
| SCHEMBL7696233 | 0.84 | KDR (0.62) | KDRCHEK1CDK1CDK2KCNH2 | |
| SCHEMBL7094335 | 0.83 | KDR (0.64) | KDRCHEK1CDK1CDK2KCNH2 | |
| SCHEMBL7002533 | 0.82 | CDK1 (0.57) | KDRCHEK1CDK1CDK2KCNH2 | |
| Hydrochloric Acid SCHEMBL7002601 | 0.82 | CDK1 (0.56) | KDRCHEK1CDK1CDK2KCNH2 | |
| SCHEMBL7000955 | 0.82 | KDR (0.65) | KDRCHEK1CDK1CDK2KIT | |
| SCHEMBL7703652 | 0.81 | KDR (0.57) | KDRCHEK1CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |