Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12049784 | 0.82 | OPRL1 (0.46) | OPRM1OPRL1PDE10A | |
| SCHEMBL15808187 | 0.79 | CHRM4 (0.44) | PDE10A | |
| SCHEMBL29879632 | 0.79 | OPRL1 (0.48) | OPRM1OPRL1 | |
| SCHEMBL8233305 | 0.79 | OPRL1 (0.48) | OPRM1OPRL1 | |
| SCHEMBL18136226 | 0.79 | KAT2B (0.38) | KAT2BPDE10A | |
| SCHEMBL2590271 | 0.77 | PDE10A (0.46) | OPRM1OPRL1PDE10A | |
| SCHEMBL21780590 | 0.76 | OPRM1 (0.47) | OPRM1OPRL1PDE10A | |
| SCHEMBL12049840 | 0.76 | OPRL1 (0.46) | OPRM1OPRL1 | |
| SCHEMBL12027329 | 0.74 | OPRM1 (0.42) | OPRM1OPRL1 | |
| Hydrochloric Acid SCHEMBL2595722 | 0.73 | OPRM1 (0.41) | OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011143365-A1 | NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |