Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 7/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | UBASH3B | Q8TF42 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863011 | 0.81 | CNR1 (0.42) | KMT2AMEN1RXFP1CNR1LMNA | |
| SCHEMBL1538310 | 0.75 | MEN1 (0.59) | KMT2AMEN1RXFP1LMNAUBASH3B | |
| SCHEMBL6868966 | 0.75 | HPGD (0.53) | KMT2AMEN1RXFP1LMNAMAPK1 | |
| SCHEMBL5758311 | 0.75 | LMNA (0.47) | KMT2AMEN1RXFP1CNR1LMNA | |
| SCHEMBL17025452 | 0.74 | KDM4E (0.49) | KMT2AMEN1RXFP1CNR1LMNA | |
| SCHEMBL5756005 | 0.74 | MEN1 (0.44) | KMT2AMEN1RXFP1CNR1LMNA | |
| SCHEMBL5722642 | 0.73 | MEN1 (0.52) | KMT2AMEN1RXFP1CNR1LMNA | |
| SCHEMBL5780432 | 0.73 | RXFP1 (0.52) | KMT2AMEN1RXFP1CNR1LMNA | |
| SCHEMBL5756770 | 0.72 | KDM4E (0.53) | KMT2AMEN1RXFP1CNR1LMNA | |
| SCHEMBL6872273 | 0.72 | FNTA (0.69) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019395-B1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2002-01-30 | — | — | EP | disclosed |
| EP-1106610-A1 | Farnesyl transferase inhibiting 2-quinolone derivatives | Janssen Pharmaceutica N.V. (BE) | 2001-06-13 | — | — | EP | disclosed |
| EP-1019395-A1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-07-19 | — | — | EP | disclosed |
| WO-1997016443-A1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-05-09 | — | — | WO | disclosed |