Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | CASP3 | P42574 | 2/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7090902 | 0.90 | MEN1 (0.51) | MEN1KMT2ACHEK1THRAKDR | |
| SCHEMBL7703594 | 0.90 | CHEK1 (0.53) | MEN1KMT2ACHEK1KDRNPC1 | |
| SCHEMBL6999716 | 0.90 | CHEK1 (0.53) | MEN1KMT2ACHEK1KDRNPC1 | |
| SCHEMBL7094928 | 0.85 | KDR (0.64) | MEN1KMT2ACHEK1KDRNPC1 | |
| SCHEMBL7093397 | 0.85 | CHEK1 (0.54) | MEN1KMT2ACHEK1KDRNPC1 | |
| Water SCHEMBL7089950 | 0.84 | KDR (0.63) | MEN1KMT2ACHEK1KDRNPC1 | |
| SCHEMBL6994408 | 0.81 | KDR (0.64) | CHEK1KDRNPC1CDK1CDK2 | |
| SCHEMBL7698430 | 0.81 | KDR (0.64) | CHEK1KDRMAPTLMNAHPGD | |
| SCHEMBL7091231 | 0.81 | CHEK1 (0.56) | CHEK1KDRCDK1CDK2 | |
| SCHEMBL7167280 | 0.81 | MEN1 (0.48) | MEN1KMT2ACHEK1KDRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |