Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 5/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CD40 | P25942 | 2/20 | 0.45 |
| ▸ | CD40LG | P29965 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999716 | 1.00 | CHEK1 (0.53) | CHEK1KDRPOLBMEN1KMT2A | |
| SCHEMBL7701674 | 0.90 | MEN1 (0.55) | CHEK1KDRPOLBMEN1KMT2A | |
| SCHEMBL7167280 | 0.89 | MEN1 (0.48) | CHEK1KDRPOLBMEN1KMT2A | |
| SCHEMBL7094928 | 0.88 | KDR (0.64) | CHEK1KDRMEN1KMT2ANPC1 | |
| SCHEMBL6994408 | 0.88 | KDR (0.64) | CHEK1KDRNPC1CDK1CDK2 | |
| Water SCHEMBL7089950 | 0.87 | KDR (0.63) | CHEK1KDRMEN1KMT2ANPC1 | |
| SCHEMBL7000839 | 0.87 | KDR (0.68) | CHEK1KDRNPC1CDK1CDK2 | |
| SCHEMBL7696243 | 0.86 | CHEK1 (0.57) | CHEK1KDRPOLBMEN1KMT2A | |
| SCHEMBL7545158 | 0.86 | CHEK1 (0.40) | CHEK1KDRPOLBMEN1KMT2A | |
| SCHEMBL7002081 | 0.85 | CDK1 (0.67) | CHEK1KDRPOLBNPC1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |