Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2630825 | 0.89 | LRRK2 (0.39) | LRRK2IRAK4MAPK1 | |
| SCHEMBL7703998 | 0.78 | FFAR2 (0.34) | LRRK2IRAK4MAPK1 | |
| SCHEMBL2630843 | 0.78 | PDE4D (0.34) | LRRK2IRAK4MAPK1 | |
| SCHEMBL2630755 | 0.77 | LRRK2 (0.33) | LRRK2MAPK1 | |
| SCHEMBL7703675 | 0.76 | SYK (0.37) | LRRK2MAPK1 | |
| SCHEMBL15300705 | 0.76 | PDE4D (0.37) | LRRK2 | |
| SCHEMBL878166 | 0.75 | LRRK2 (0.42) | LRRK2 | |
| SCHEMBL2630721 | 0.73 | LRRK2 (0.41) | LRRK2IRAK4MAPK1 | |
| SCHEMBL10225781 | 0.72 | LRRK2 (0.56) | LRRK2 | |
| SCHEMBL883637 | 0.71 | LRRK2 (0.41) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011141756-A1 | PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2 | MEDICAL RESEARCH COUNCIL TECHNOLOGY (GB) | 2011-11-17 | — | — | WO | disclosed |