SCHEMBL7701958

SCHEMBL7701958

[CH2]OC(C)(OC)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.44
ALDH1A1 P00352 3/20 0.41
ALOX15 P16050 1/20 0.41
CES1 P23141 1/20 0.38
KCNN4 O15554 4/20 0.38
TAAR1 Q96RJ0 1/20 0.37
ESR1 P03372 2/20 0.35
ESR2 Q92731 2/20 0.35
CYP3A4 P08684 1/20 0.35
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34
TSHR P16473 2/20 0.33
CYP2C19 P33261 1/20 0.33
HIF1A Q16665 1/20 0.33
CA4 P22748 1/20 0.33
NR3C2 P08235 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL204375 0.85 MAPK1 (0.52) MAPK1ALDH1A1ALOX15CES1KCNN4
SCHEMBL11747840 0.76 MAPK1 (0.43) MAPK1ALDH1A1ALOX15CES1KCNN4
SCHEMBL15093614 0.73 MAPK1 (0.64) MAPK1ALDH1A1ALOX15KCNN4TAAR1
SCHEMBL4372562 0.73 CES1 (0.47) MAPK1ALDH1A1ALOX15CES1KCNN4
SCHEMBL7873647 0.71 MAPK1 (0.54) MAPK1ALDH1A1ALOX15CES1KCNN4
SCHEMBL9047900 0.71 MAPK1 (0.48) MAPK1ALDH1A1ALOX15CES1KCNN4
SCHEMBL3844071 0.70 MAPK1 (0.52) MAPK1ALDH1A1ALOX15CES1KCNN4
SCHEMBL42639 0.70 MAPK1 (0.67) MAPK1ALDH1A1ALOX15CES1KCNN4
SCHEMBL664301 0.70 MAPK1 (0.52) MAPK1ALDH1A1ALOX15CES1KCNN4
Hydrochloric Acid SCHEMBL11440160 0.70 CES1 (0.44) MAPK1ALDH1A1ALOX15CES1KCNN4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6342501-B1 VIRICIDES THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2002-01-29 US disclosed
WO-2000042043-A1 PYRROLO[2,3-d]PYRIMIDINES AS ANTIVIRAL AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2000-07-20 WO disclosed
EP-0746559-A1 PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES AS ANTIVIRALS The Regents of The University of Michigan (US) 1996-12-11 EP disclosed
US-5543413-A VIRAL ACTIVITY AGAINST HUMAN CYTOMEGALOVIRUS AND HERPES SIMPLEX VIRUS REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1996-08-06 US disclosed
WO-1995023151-A1 PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES AS ANTIVIRALS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1995-08-31 WO disclosed