Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.49 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7214328 | 0.88 | DRD2 (0.65) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL7215170 | 0.87 | DRD2 (0.64) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL7214030 | 0.87 | DRD2 (0.54) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL7220408 | 0.84 | DRD2 (0.53) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| Oxalic Acid SCHEMBL7214504 | 0.83 | HTR1D (0.54) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL7214517 | 0.81 | DRD2 (0.60) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL7213620 | 0.81 | HTR1D (0.56) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL7513552 | 0.75 | HTR1D (0.49) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL7213744 | 0.73 | DRD2 (0.56) | DRD2HTR1ASLC6A4HTR7HTR6 | |
| SCHEMBL7213683 | 0.73 | DRD2 (0.57) | DRD2HTR1ASLC6A4HTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6352988-B2 | HIGH AFFINITY FOR D4 RECEPTORS; TREATMENT OF SCHIZOPHRENIA, OTHER PSYCHOSES, ANXIETY DISORDERS, DEPRESSION, ALCOHOL ABUSE, IMPULSE CONTROL DISORDERS, AGGRESSION | H. LUNDBECK A/S (DK) | 2002-03-05 | — | — | US | disclosed |