Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.56 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.43 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL52160 | 0.83 | — | — | |
| Glycolic Acid SCHEMBL11314615 | 0.81 | TSHR (0.46) | EGLN1LMNAALKBH5SUCNR1TSHR | |
| Malonic Acid SCHEMBL5568061 | 0.81 | LDHA (0.56) | EGLN1LMNAALKBH5SUCNR1TSHR | |
| Succinic Acid SCHEMBL19181068 | 0.81 | EGLN1 (0.56) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Succinic Acid SCHEMBL8052773 | 0.79 | EGLN1 (0.75) | EGLN1LMNAALKBH5SUCNR1SLC15A2 | |
| Hydrochloric Acid SCHEMBL4682921 | 0.79 | TSHR (0.53) | LMNATSHRCYP2D6CYP2C19HIF1A | |
| Hydrochloric Acid SCHEMBL808934 | 0.79 | TSHR (0.53) | LMNATSHRCYP2D6CYP2C19HIF1A | |
| SCHEMBL11587164 | 0.79 | TSHR (0.53) | TSHRCYP2D6CYP2C19HIF1AFFAR3 | |
| SCHEMBL107651 | 0.79 | TSHR (0.53) | TSHRCYP2D6CYP2C19HIF1AFFAR3 | |
| SCHEMBL106724 | 0.79 | TSHR (0.53) | TSHRCYP2D6CYP2C19HIF1AFFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189875-A2 | MONO AND MULTIFUNCTIONAL ALKOXYAMINES FOR THE PREPARATION OF FUNCTIONALIZED MACROMERS | Ciba SC Holding AG (CH) | 2002-03-27 | — | — | EP | disclosed |
| WO-2001002345-A2 | MONO AND MULTIFUNCTIONAL ALKOXYAMINES FOR THE PREPARATION OF FUNCTIONALIZED MACROMERS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2001-01-11 | — | — | WO | disclosed |