Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.81 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.81 |
| ▸ | LMNA | P02545 | 6/20 | 0.74 |
| ▸ | MAPT | P10636 | 9/20 | 0.63 |
| ▸ | THRB | P10828 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7702434 | 0.90 | HCRTR1 (0.88) | HCRTR1HCRTR2LMNAMAPTTHRB | |
| SCHEMBL7709772 | 0.90 | HCRTR1 (1.00) | HCRTR1HCRTR2LMNAMAPTTHRB | |
| SCHEMBL7704054 | 0.89 | HCRTR1 (0.83) | HCRTR1HCRTR2LMNAMAPTTHRB | |
| SCHEMBL7704850 | 0.89 | HCRTR1 (0.81) | HCRTR1HCRTR2LMNAMAPTTHRB | |
| SCHEMBL7711132 | 0.87 | HCRTR1 (0.78) | HCRTR1HCRTR2LMNAMAPTTHRB | |
| SCHEMBL7707089 | 0.86 | HCRTR1 (0.77) | HCRTR1HCRTR2LMNAMAPTTHRB | |
| SCHEMBL7703511 | 0.85 | HCRTR1 (0.90) | HCRTR1HCRTR2LMNAMAPTTHRB | |
| SCHEMBL7703516 | 0.85 | HCRTR1 (0.90) | HCRTR1HCRTR2LMNAMAPTTHRB | |
| SCHEMBL2594733 | 0.84 | HCRTR1 (0.96) | HCRTR1HCRTR2LMNAMAPTTHRB | |
| SCHEMBL7711063 | 0.84 | HCRTR1 (0.96) | HCRTR1HCRTR2LMNAMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |