Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.90 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.90 |
| ▸ | POLB | P06746 | 7/20 | 0.76 |
| ▸ | LMNA | P02545 | 4/20 | 0.76 |
| ▸ | THRB | P10828 | 1/20 | 0.76 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TSPO | P30536 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703516 | 1.00 | HCRTR1 (0.90) | HCRTR1HCRTR2POLBLMNATHRB | |
| SCHEMBL7709772 | 0.95 | HCRTR1 (1.00) | HCRTR1HCRTR2POLBLMNATHRB | |
| SCHEMBL2594733 | 0.91 | HCRTR1 (0.96) | HCRTR1HCRTR2POLBLMNATHRB | |
| SCHEMBL7711063 | 0.91 | HCRTR1 (0.96) | HCRTR1HCRTR2POLBLMNATHRB | |
| SCHEMBL7702434 | 0.91 | HCRTR1 (0.88) | HCRTR1HCRTR2POLBLMNATHRB | |
| SCHEMBL7704054 | 0.90 | HCRTR1 (0.83) | HCRTR1HCRTR2POLBLMNATHRB | |
| SCHEMBL7712438 | 0.89 | HCRTR1 (0.85) | HCRTR1HCRTR2POLBLMNATHRB | |
| SCHEMBL7707718 | 0.89 | HCRTR1 (1.00) | HCRTR1HCRTR2POLBLMNATHRB | |
| SCHEMBL7712442 | 0.88 | HCRTR1 (0.83) | HCRTR1HCRTR2POLBLMNATHRB | |
| SCHEMBL7707031 | 0.88 | LMNA (0.75) | HCRTR1HCRTR2POLBLMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |