Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tasimelteon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B known ✓ | P49286 | 18/20 | 1.00 |
| ▸ | MTNR1A known ✓ | P48039 | 17/20 | 0.56 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tasimelteon SCHEMBL3505909 | 1.00 | MTNR1B (1.00) | MTNR1BMTNR1ASLC9A1ABCB11SIGMAR1 | |
| Tasimelteon SCHEMBL15805072 | 1.00 | MTNR1B (1.00) | MTNR1BMTNR1ASLC9A1ABCB11SIGMAR1 | |
| Tasimelteon SCHEMBL15805116 | 1.00 | MTNR1B (1.00) | MTNR1BMTNR1ASLC9A1ABCB11SIGMAR1 | |
| Tasimelteon SCHEMBL29351713 | 1.00 | MTNR1B (1.00) | MTNR1BMTNR1ASLC9A1ABCB11SIGMAR1 | |
| Tasimelteon SCHEMBL17269306 | 1.00 | MTNR1B (1.00) | MTNR1BMTNR1ASLC9A1ABCB11SIGMAR1 | |
| Tasimelteon SCHEMBL15142113 | 1.00 | MTNR1B (1.00) | MTNR1BMTNR1ASLC9A1ABCB11SIGMAR1 | |
| Tasimelteon SCHEMBL23499868 | 1.00 | MTNR1B (1.00) | MTNR1BMTNR1ASLC9A1ABCB11SIGMAR1 | |
| Tasimelteon SCHEMBL3505912 | 1.00 | MTNR1B (1.00) | MTNR1BMTNR1ASLC9A1ABCB11SIGMAR1 | |
| SCHEMBL6677570 | 0.93 | MTNR1B (0.87) | MTNR1BMTNR1ASLC9A1ABCB11SIGMAR1 | |
| SCHEMBL6677567 | 0.93 | MTNR1B (0.87) | MTNR1BMTNR1ASLC9A1ABCB11SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082115-A4 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2002-10-24 | — | — | EP | claimed |
| US-6214869-B1 | SLEEP DISORDERS | BRISTOL-MYERS SQUIBB | 2001-04-10 | — | — | US | claimed |
| EP-1082115-A1 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-14 | — | — | EP | claimed |
| WO-1999062515-A1 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-09 | — | — | WO | claimed |
| EP-1082115-A4 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2002-10-24 | — | — | EP | disclosed |
| US-6214869-B1 | SLEEP DISORDERS | BRISTOL-MYERS SQUIBB | 2001-04-10 | — | — | US | disclosed |
| EP-1082115-A1 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062515-A1 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-09 | — | — | WO | disclosed |