Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 2/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL7703444 | 0.83 | SLC6A9 (0.62) | SLC6A9MTNR1AMTNR1BSIGMAR1TACR1 | |
| Lithium Ion SCHEMBL7698448 | 0.81 | SLC6A9 (0.54) | SLC6A9MTNR1AMTNR1BTRPM8SIGMAR1 | |
| Lithium Ion SCHEMBL7704198 | 0.81 | SLC6A9 (0.51) | SLC6A9MTNR1AMTNR1BSIGMAR1BLM | |
| Lithium Ion SCHEMBL7702844 | 0.80 | SLC6A9 (0.63) | SLC6A9MTNR1AMTNR1BSIGMAR1TACR1 | |
| Lithium Ion SCHEMBL7702768 | 0.80 | SLC6A9 (0.60) | SLC6A9MTNR1AMTNR1BTACR1 | |
| Lithium Ion SCHEMBL7698462 | 0.78 | SLC6A9 (0.69) | SLC6A9MTNR1AMTNR1BTRPM8TACR1 | |
| Org-25935 SCHEMBL7704305 | 0.78 | SLC6A9 (0.85) | SLC6A9MTNR1AMTNR1B | |
| Org-25935 SCHEMBL7703028 | 0.78 | SLC6A9 (0.85) | SLC6A9MTNR1AMTNR1B | |
| Lithium Ion SCHEMBL7700187 | 0.77 | SLC6A9 (0.70) | SLC6A9MTNR1AMTNR1BKDM4C | |
| Lithium Ion SCHEMBL7698371 | 0.77 | SLC6A9 (0.53) | SLC6A9MTNR1AMTNR1BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100769-B1 | AMINOMETHYLCARBOXYLIC ACID DERIVATIVES | AKZO NOBEL NV (NL) | 2002-12-04 | — | — | EP | disclosed |
| US-6410592-B1 | THERAPY FOR CENTRAL NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS | AKZO NOBEL N.V. (NL) | 2002-06-25 | — | — | US | disclosed |