Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 9/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.45 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6028532 | 0.83 | F2 (0.47) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7341001 | 0.81 | F2 (0.56) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL6027957 | 0.80 | F2 (0.48) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL14423556 | 0.77 | F2 (0.41) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL14423545 | 0.77 | F2 (0.46) | F2PRSS1PRSS2PRSS3HPGD | |
| SCHEMBL473144 | 0.76 | CASP1 (0.48) | CASP1CASP3CASP7CASP8ELANE | |
| SCHEMBL473145 | 0.76 | CASP1 (0.48) | CASP1CASP3CASP7CASP8ELANE | |
| SCHEMBL4902533 | 0.76 | NPC1 (0.53) | CASP1CASP3CASP7CASP8ELANE | |
| SCHEMBL12273254 | 0.76 | NPC1 (0.53) | CASP1CASP3CASP7CASP8ELANE | |
| SCHEMBL5117233 | 0.74 | F2 (0.58) | F2PRSS1ACLYPRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6342504-B1 | PEPTIDES AS ANTITHROMBINS AND ANTICOAGULANTS | CORVAS INTERNATIONAL, INC. | 2002-01-29 | — | — | US | disclosed |
| US-5656645-A | INHIBITORS OF THROMBIN | CORVAS INTERNATIONAL, INC. (US) | 1997-08-12 | — | — | US | disclosed |