Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7697888 | 0.93 | CHEK1 (0.57) | CHEK1KDRCDK1CDK2MEN1 | |
| SCHEMBL7094478 | 0.89 | CHEK1 (0.49) | CHEK1KDRCDK1ROCK2DCLK1 | |
| SCHEMBL7702867 | 0.85 | CHEK1 (0.53) | CHEK1KDRCDK1CDK2TDP1 | |
| SCHEMBL7700585 | 0.85 | CHEK1 (0.53) | CHEK1KDRCDK1CDK2ROCK2 | |
| SCHEMBL7696243 | 0.83 | CHEK1 (0.57) | CHEK1KDRCDK1CDK2ROCK2 | |
| SCHEMBL7093397 | 0.82 | CHEK1 (0.54) | CHEK1KDRCDK1CDK2ROCK2 | |
| SCHEMBL7094928 | 0.82 | KDR (0.64) | CHEK1KDRCDK1CDK2ROCK2 | |
| SCHEMBL7091231 | 0.82 | CHEK1 (0.56) | CHEK1KDRCDK1CDK2ROCK2 | |
| Water SCHEMBL7089950 | 0.81 | KDR (0.63) | CHEK1KDRCDK1CDK2ROCK2 | |
| SCHEMBL6998221 | 0.81 | NPC1 (0.52) | CHEK1KDRMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |