Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 12/20 | 0.61 |
| ▸ | HTR2C | P28335 | 5/20 | 0.61 |
| ▸ | HTR3A | P46098 | 5/20 | 0.61 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.61 |
| ▸ | HTR3B | O95264 | 2/20 | 0.61 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.61 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.60 |
| ▸ | HTR1D | P28221 | 3/20 | 0.60 |
| ▸ | HTR2B | P41595 | 3/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.60 |
| ▸ | HTR2A | P28223 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | HRH1 | P35367 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703087 | 1.00 | HTR4 (0.61) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL7703085 | 1.00 | HTR4 (0.61) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL7706528 | 0.91 | HTR4 (0.50) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL7706524 | 0.91 | HTR4 (0.50) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL855704 | 0.88 | HTR4 (0.77) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL855705 | 0.88 | HTR4 (0.77) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| SCHEMBL855706 | 0.88 | HTR4 (0.77) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| Oxalic Acid SCHEMBL7708674 | 0.85 | HTR4 (0.61) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| Oxalic Acid SCHEMBL7708677 | 0.85 | HTR4 (0.61) | HTR4HTR2CHTR3AHTR3EHTR3B | |
| Oxalic Acid SCHEMBL7708672 | 0.85 | HTR4 (0.61) | HTR4HTR2CHTR3AHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880500-B1 | ESTERS OF 3-HYDROXY-PIPERIDINEMETHANOL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2002-07-31 | — | — | EP | disclosed |
| US-6096761-A | REACTING A N-SUBSTITUTED 4-METHANOL-3-HYDROXY OR ALKOXY-PIPERIDINE INTERMEDIATE WITH A CARBOXYLIC ACID DERIVATIVES; ADMINISTERING TO AN ANIMAL SUFFERING WITH A CONDITION RELATED TO HAMPERED OR IMPAIRED GASTRIC EMPTYING | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-08-01 | — | — | US | disclosed |