SCHEMBL7703424

SCHEMBL7703424

NC(=O)Nc1ccc(OCC(O)CN2CC=C(c3ccc(F)cc3)CC2)cc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 1/20 0.79
THPO P40225 1/20 0.79
LMNA P02545 2/20 0.77
PMP22 Q01453 1/20 0.77
KCNH2 Q12809 2/20 0.55
TSHR P16473 3/20 0.49
MAPT P10636 3/20 0.49
ALDH1A1 P00352 2/20 0.49
ALOX15 P16050 2/20 0.49
KDM4E B2RXH2 1/20 0.49
GAA P10253 1/20 0.49
ABCB1 P08183 5/20 0.46
PPARG P37231 1/20 0.45
PPARA Q07869 1/20 0.45
HSD17B10 Q99714 1/20 0.45
CACNA1G O43497 1/20 0.44
SIGMAR1 Q99720 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
NAMPT P43490 1/20 0.44
NPC1 O15118 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6021254 0.88 CYP2D6 (1.00) CYP2D6THPOLMNAPMP22TSHR
SCHEMBL7702263 0.88 CYP2D6 (0.67) CYP2D6THPOLMNAPMP22KCNH2
Hydrochloric Acid SCHEMBL2001258 0.87 LMNA (1.00) CYP2D6THPOLMNAPMP22TSHR
SCHEMBL7697676 0.85 CYP2D6 (0.67) CYP2D6THPOLMNAPMP22KCNH2
SCHEMBL7860449 0.84 CYP2D6 (0.67) CYP2D6THPOLMNAPMP22KCNH2
SCHEMBL12618637 0.83 CYP2D6 (0.74) CYP2D6THPOLMNAPMP22TSHR
SCHEMBL2017339 0.81 KCNH2 (0.81) LMNAKCNH2MAPTABCB1CACNA1G
SCHEMBL2017338 0.81 KCNH2 (0.81) LMNAKCNH2MAPTABCB1CACNA1G
SCHEMBL2024028 0.81 KCNH2 (0.81) LMNAKCNH2MAPTABCB1CACNA1G
SCHEMBL7861690 0.79 CYP2D6 (0.71) CYP2D6THPOLMNAPMP22TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0885004-B1 USE OF 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS NMDA RECEPTOR SUBTYPE BLOCKERS HOFFMANN LA ROCHE (CH) 2002-05-02 EP claimed
EP-0885004-A1 USE OF 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS NMDA RECEPTOR SUBTYPE BLOCKERS F.HOFFMANN-LA ROCHE AG (CH) 1998-12-23 EP claimed
WO-1997032581-A1 USE OF 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS NMDA RECEPTOR SUBTYPE BLOCKERS F. HOFFMANN-LA ROCHE AG (CH) 1997-09-12 WO claimed
EP-0885004-B1 USE OF 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS NMDA RECEPTOR SUBTYPE BLOCKERS HOFFMANN LA ROCHE (CH) 2002-05-02 EP disclosed
EP-0885004-A1 USE OF 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS NMDA RECEPTOR SUBTYPE BLOCKERS F.HOFFMANN-LA ROCHE AG (CH) 1998-12-23 EP disclosed
WO-1997032581-A1 USE OF 4-PHENYL-3,6-DIHYDRO-2H-PYRIDYL DERIVATIVES AS NMDA RECEPTOR SUBTYPE BLOCKERS F. HOFFMANN-LA ROCHE AG (CH) 1997-09-12 WO disclosed