SCHEMBL7703440

SCHEMBL7703440

CSCC[C@H](NC(=O)c1ccc(C=C(Cn2cncc2C)c2ccc(F)cc2)cc1-c1ccccc1)C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FNTA P49354 14/20 0.53
FNTB P49356 14/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7703436 1.00 FNTA (0.53) FNTAFNTB
SCHEMBL7703311 0.90 FNTA (0.41) FNTAFNTB
SCHEMBL7703319 0.90 FNTA (0.41) FNTAFNTB
SCHEMBL7703338 0.87 FNTA (0.48) FNTAFNTB
SCHEMBL7703335 0.87 FNTA (0.48) FNTAFNTB
SCHEMBL7706086 0.86 FNTA (0.55) FNTAFNTB
SCHEMBL7706082 0.86 FNTA (0.55) FNTAFNTB
SCHEMBL7703301 0.84 FNTA (0.52) FNTAFNTB
SCHEMBL7703293 0.84 FNTA (0.52) FNTAFNTB
SCHEMBL8360606 0.84 FNTA (0.52) FNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6414145-B1 TREATING CANCER AND NEUROFIBROMATOSIS ZENECA LIMITED (GB) 2002-07-02 US claimed
US-6414145-B1 TREATING CANCER AND NEUROFIBROMATOSIS ZENECA LIMITED (GB) 2002-07-02 US disclosed
EP-0975603-A1 INHIBITORS OF FARNESYL PROTEIN TRANSFERASE ZENECA LIMITED (GB) 2000-02-02 EP disclosed
WO-1998032741-A1 INHIBITORS OF FARNESYL PROTEIN TRANSFERASE ZENECA LIMITED (GB) 1998-07-30 WO disclosed