Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 5/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | F10 | P00742 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4928004 | 0.82 | AKT3 (0.73) | AKT3HDAC1HDAC3HDAC4HDAC6 | |
| SCHEMBL4923388 | 0.82 | ACKR3 (0.67) | AKT3HDAC1HDAC3HDAC4HDAC6 | |
| SCHEMBL5003717 | 0.80 | AKT3 (1.00) | AKT3HDAC1 | |
| SCHEMBL6972046 | 0.79 | HDAC1 (0.77) | HDAC1HDAC3HDAC4HDAC6HDAC7 | |
| SCHEMBL5903774 | 0.79 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC6HDAC7 | |
| SCHEMBL13887791 | 0.79 | AKT1 (0.63) | AKT3HDAC1HDAC3HDAC4HDAC6 | |
| SCHEMBL31337390 | 0.78 | HDAC1 (0.57) | AKT3HDAC1HDAC3HDAC4HDAC6 | |
| SCHEMBL14273322 | 0.78 | AKT3 (0.51) | AKT3HDAC1HDAC3HDAC4HDAC6 | |
| SCHEMBL5124152 | 0.78 | AKT3 (0.51) | AKT3HDAC1HDAC3HDAC4HDAC6 | |
| SCHEMBL8567491 | 0.76 | HDAC1 (0.77) | HDAC1HDAC3HDAC4HDAC6HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |