Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.77 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.77 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.77 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.77 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.77 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.77 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.77 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.77 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.77 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | PPARG | P37231 | 1/20 | 0.63 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.63 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5903774 | 0.87 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL8567491 | 0.84 | HDAC1 (0.77) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL359879 | 0.82 | KDM4E (0.73) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL27623934 | 0.82 | KDM4E (0.77) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL7902381 | 0.81 | KDM4E (0.67) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5224376 | 0.80 | NPC1 (0.73) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL373105 | 0.80 | KDM4E (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL29631004 | 0.80 | KDM4E (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL7703536 | 0.79 | AKT3 (0.67) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL9374034 | 0.79 | KDM4E (0.73) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0911331-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-0911331-A2 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1999-04-28 | — | — | EP | disclosed |
| US-5576315-A | Substituted dibenzoxazepine compounds and methods for treating osteoporosis and ischemia | G.D. SEARLE & CO. (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0694545-A2 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1996-01-31 | — | — | EP | disclosed |
| EP-0694546-A2 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. SEARLE & CO. (US) | 1996-01-31 | — | — | EP | disclosed |
| US-5464830-A | ANALGESICS | G. D. SEARLE & CO. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5378840-A | Substituted dibenzoxazepine compounds | G. D. SEARLE & CO. (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0583421-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1994-02-23 | — | — | EP | disclosed |
| WO-1992019617-A2 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1992-11-12 | — | — | WO | disclosed |
| EP-0512400-A1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | G.D. Searle & Co. (US) | 1992-11-11 | — | — | EP | disclosed |