Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.52 |
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | KDM5C | P41229 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215104 | 0.81 | KDM5B (0.71) | KDM4EALDH1A1HIF1ARAB9ANPC1 | |
| SCHEMBL7702882 | 0.80 | RAB9A (0.60) | KDM4EALDH1A1HIF1ARAB9ANPC1 | |
| SCHEMBL6072210 | 0.80 | HIF1A (0.59) | KDM4EHIF1ARAB9ANPC1KDM5B | |
| SCHEMBL7699651 | 0.80 | KDM5B (0.57) | KDM4EALDH1A1HIF1ARAB9ANPC1 | |
| SCHEMBL30131466 | 0.78 | KMT2A (0.69) | KDM4EALDH1A1HIF1ARAB9ANPC1 | |
| SCHEMBL7704092 | 0.78 | KMT2A (0.69) | KDM4EALDH1A1HIF1ARAB9ANPC1 | |
| SCHEMBL9154280 | 0.77 | TMEM97 (0.70) | KDM4EALDH1A1RAB9ANPC1KDM5B | |
| SCHEMBL2464624 | 0.76 | KDM4E (0.65) | KDM4EALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL7698230 | 0.74 | KMT2A (0.68) | HIF1ARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14292560 | 0.73 | RAB9A (0.65) | KDM4EALDH1A1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901488-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | BASILEA PHARMACEUTICA AG (CH) | 2002-11-06 | — | — | EP | disclosed |
| EP-0901488-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-17 | — | — | EP | disclosed |
| US-5866583-A | Substituted 2,4-diaminopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1999-02-02 | — | — | US | disclosed |
| WO-1997043277-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-20 | — | — | WO | disclosed |