Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872485 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL6868503 | 0.79 | KMT2A (0.64) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL6868506 | 0.79 | TACR1 (0.56) | — | |
| SCHEMBL12126619 | 0.73 | MAPT (0.54) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL7703582 | 0.73 | RXFP1 (0.46) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL6016328 | 0.73 | RXFP1 (0.53) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL6866229 | 0.71 | MAPT (0.58) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL6862548 | 0.71 | TACR1 (0.40) | SMN1; SMN2MAPTNPC1RXFP1AURKA | |
| SCHEMBL6862075 | 0.70 | AURKA (0.45) | SMN1; SMN2MEN1KMT2AMAPTLMNA | |
| SCHEMBL6862070 | 0.69 | HSP90AA1 (0.47) | SMN1; SMN2MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187814-A2 | 5-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000073278-A2 | 5-PHENYL-PYRIMIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-07 | — | — | WO | disclosed |