Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | RGS12 | O14924 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7706709 | 0.87 | MEN1 (0.46) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL7709560 | 0.85 | ALDH1A1 (0.44) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL7712257 | 0.82 | MEN1 (0.46) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL7709580 | 0.79 | KMT2A (0.68) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL7709423 | 0.76 | NTRK1 (0.57) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL7703791 | 0.74 | MAPT (0.49) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL7706804 | 0.74 | HTT (0.47) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL7703771 | 0.73 | KMT2A (0.51) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL7712197 | 0.73 | CYP1B1 (0.65) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL5532596 | 0.71 | ALDH1A1 (0.58) | MEN1KMT2AMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-6177423-B1 | N-(HYDROXY OR PROTECTED HYDROXY)-BENZO(DE)ISOQUINOLINE-1,3-DIONE DERIVATIVES; BACTERIAL DNA GYRASE AND DNA TOPOISOMERASE INHIBITORS USEFUL FOR ANTIBACTERIAL AGENTS HAVING REDUCED DRUG RESISTANCE AND REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | disclosed |