Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8700087 | 0.80 | BCHE (0.44) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL2242248 | 0.76 | BCHE (0.44) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL12428929 | 0.76 | RARB (0.41) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL26443454 | 0.76 | RARB (0.39) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL7703904 | 0.74 | RARB (0.48) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL9379048 | 0.70 | RARB (0.43) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL11988473 | 0.69 | RARB (0.52) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL2242664 | 0.69 | CYP1A2 (0.49) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL14827606 | 0.69 | HDAC3 (0.44) | RARBRARGHDAC3HDAC4HDAC1 | |
| SCHEMBL31714583 | 0.69 | RARB (0.40) | RARBRARGHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228042-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | Allergan Sales, Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001012606-A2 | TETRAHYDROQUINOLINE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 2001-02-22 | — | — | WO | disclosed |