Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 9/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139709 | 0.92 | HDAC1 (0.36) | HDAC2HDAC1HDAC3MEN1KMT2A | |
| SCHEMBL7148407 | 0.80 | ADRA2A (0.33) | MEN1KMT2AL3MBTL1 | |
| SCHEMBL7139872 | 0.75 | HDAC1 (0.39) | HDAC2HDAC1HDAC3CREBBP | |
| SCHEMBL7698739 | 0.75 | CREBBP (0.37) | HDAC2HDAC1HDAC3MEN1KMT2A | |
| SCHEMBL7142689 | 0.71 | KDM4D (0.33) | — | |
| SCHEMBL7143646 | 0.70 | MEN1 (0.38) | HDAC2HDAC1HDAC3MEN1KMT2A | |
| SCHEMBL7139841 | 0.68 | HDAC3 (0.38) | HDAC2HDAC1HDAC3MEN1KMT2A | |
| SCHEMBL7700560 | 0.65 | CREBBP (0.37) | HDAC2HDAC1HDAC3MEN1KMT2A | |
| SCHEMBL7145150 | 0.64 | ADRA2A (0.35) | MEN1KMT2AL3MBTL1CREBBP | |
| SCHEMBL7141349 | 0.63 | HDAC1 (0.45) | HDAC2HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224174-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001029011-A2 | BENZODIAZEPINE DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-26 | — | — | WO | disclosed |