SCHEMBL7704790

SCHEMBL7704790

CC(C)(O)CCCC(C)(C)CCCC=O

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.38
HIF1A Q16665 1/20 0.38
TSHR P16473 2/20 0.37
FFAR1 O14842 1/20 0.35
CPT2 P23786 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
MEN1 O00255 1/20 0.33
POLB P06746 1/20 0.33
APEX1 P27695 1/20 0.33
KMT2A Q03164 1/20 0.33
CTDSP1 Q9GZU7 1/20 0.33
MAPT P10636 1/20 0.32
ACLY P53396 1/20 0.31
FAAH O00519 2/20 0.31
TRPV1 Q8NER1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27509626 0.91
SCHEMBL17520243 0.82 TSHR (0.48) ALDH1A1HIF1ATSHRFFAR1CPT2
SCHEMBL17500181 0.82 TSHR (0.48) ALDH1A1HIF1ATSHRFFAR1CPT2
SCHEMBL9391580 0.82 TSHR (0.48) ALDH1A1HIF1ATSHRFFAR1CPT2
SCHEMBL12204769 0.82 TSHR (0.48) ALDH1A1HIF1ATSHRFFAR1CPT2
SCHEMBL27785813 0.81 TSHR (0.46) ALDH1A1HIF1ATSHRFFAR1CPT2
SCHEMBL7702831 0.80 TSHR (0.32) HIF1ATSHRFFAR1CPT2TDP1
SCHEMBL17822143 0.78 ACLY (0.44) ALDH1A1HIF1ATSHRMAPTACLY
SCHEMBL17822145 0.78 ACLY (0.44) ALDH1A1HIF1ATSHRMAPTACLY
SCHEMBL1783206 0.77 TSHR (0.59) ALDH1A1HIF1ATSHRFFAR1CPT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1056716-B1 CYCLOHEXANEDIOLE DERIVATIVES BASILEA PHARMACEUTICA AG (CH) 2002-12-11 EP disclosed
US-6184422-B1 TREATMENT AND PREVENTION OF HYPERPROLIFERATIVE SKIN DISEASES; REVERSING CONDITIONS ASSOCIATED WITH PHOTODAMAGE; ANTITUMOR, -CARCINOGENIC AGENTS; PSORIASIS; DISORDERS OF NEOPLASTIC DISEASES; KERATINIZATION/KERATOSIS; ACNE; SEBORRHEA HOFFMAN-LA ROCHE INC. 2001-02-06 US disclosed
EP-1056716-A1 CYCLOHEXANEDIOLE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2000-12-06 EP disclosed
WO-1999043646-A1 CYCLOHEXANEDIOLE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-09-02 WO disclosed