Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 10/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873979 | 0.84 | CDK8 (0.37) | MAP3K11CHEK2CHEK1EPHX2AXL | |
| SCHEMBL5873978 | 0.84 | CDK8 (0.37) | MAP3K11CHEK2CHEK1EPHX2AXL | |
| SCHEMBL5873818 | 0.83 | CHEK2 (0.35) | MAP3K11CHEK2CHEK1EPHX2AXL | |
| SCHEMBL5873832 | 0.83 | CHEK2 (0.35) | MAP3K11CHEK2CHEK1EPHX2AXL | |
| SCHEMBL5170979 | 0.81 | IKBKB (0.41) | MAP3K11CHEK2CHEK1EPHX2JAK3 | |
| SCHEMBL5419132 | 0.81 | IKBKB (0.41) | MAP3K11CHEK2CHEK1EPHX2JAK3 | |
| SCHEMBL5873840 | 0.81 | PTK2 (0.35) | MAP3K11CHEK2AXLJAK3MET | |
| SCHEMBL5873838 | 0.81 | PTK2 (0.35) | MAP3K11CHEK2AXLJAK3MET | |
| SCHEMBL5873801 | 0.80 | JAK3 (0.36) | MAP3K11CHEK2CHEK1AXLJAK3 | |
| SCHEMBL5873805 | 0.80 | JAK3 (0.36) | MAP3K11CHEK2CHEK1AXLJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350747-B1 | PROTEIN SERINE/THREONINE KINASE AND PROTEIN TYROSINE KINASE ENZYME INHIBITORS; ANGIOGENESIS INHIBITORS; ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | GLAXO WELLCOME INC. | 2002-02-26 | — | — | US | disclosed |