Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 10/20 | 0.35 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873818 | 1.00 | CHEK2 (0.35) | CHEK2MAP3K11CHEK1JAK3IKBKE | |
| SCHEMBL5873838 | 0.87 | PTK2 (0.35) | CHEK2MAP3K11JAK3AXLMET | |
| SCHEMBL5873840 | 0.87 | PTK2 (0.35) | CHEK2MAP3K11JAK3AXLMET | |
| SCHEMBL5873793 | 0.87 | JAK3 (0.39) | MAP3K11CHEK1JAK3IKBKETBK1 | |
| SCHEMBL5873796 | 0.87 | JAK3 (0.39) | MAP3K11CHEK1JAK3IKBKETBK1 | |
| SCHEMBL5873979 | 0.84 | CDK8 (0.37) | CHEK2MAP3K11CHEK1JAK3AXL | |
| SCHEMBL5873978 | 0.84 | CDK8 (0.37) | CHEK2MAP3K11CHEK1JAK3AXL | |
| SCHEMBL7704861 | 0.83 | MAP3K11 (0.40) | CHEK2MAP3K11CHEK1JAK3IKBKE | |
| SCHEMBL5873953 | 0.82 | NTRK1 (0.41) | — | |
| SCHEMBL5873956 | 0.82 | NTRK1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7129253-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-31 | — | — | US | disclosed |
| US-6818632-B2 | 3-(anilinomethylene)oxindoles | SMITHKLINE BEECHAM CORPORATION | 2004-11-16 | — | — | US | disclosed |
| US-6498176-B1 | INHIBITING TUMOR GROWTH VIA INHIBITION OF TUMOR-RELATED ANGIOGENESIS | SMITHKLINEBEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |
| EP-1165514-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000056710-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-09-28 | — | — | WO | disclosed |