Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8272028 | 0.86 | PDE10A (0.75) | PDE10AMAPTHPGDTSHRKMT2A | |
| SCHEMBL7709375 | 0.84 | PDE10A (0.58) | PDE10AMAPTHPGDTSHRMEN1 | |
| SCHEMBL7703632 | 0.83 | PDE10A (0.59) | PDE10AMAPTHPGDTSHRMEN1 | |
| SCHEMBL7709951 | 0.80 | PDE10A (0.56) | PDE10AMAPTHPGDTSHRMEN1 | |
| SCHEMBL7709755 | 0.77 | PDE10A (0.73) | PDE10AHPGDTSHRCYP17A1CYP19A1 | |
| SCHEMBL8271910 | 0.77 | PDE10A (0.73) | PDE10AHPGDTSHRKMT2ACYP17A1 | |
| SCHEMBL8271482 | 0.76 | PDE10A (0.71) | PDE10AHPGDTSHRCYP17A1CYP19A1 | |
| SCHEMBL2560664 | 0.75 | PDE10A (0.70) | PDE10AHPGDTSHRCYP17A1CYP19A1 | |
| SCHEMBL2577947 | 0.75 | PDE10A (0.79) | PDE10ATSHRCYP17A1CYP19A1CYP11B1 | |
| SCHEMBL8272706 | 0.74 | PDE10A (0.67) | PDE10AMAPTHPGDTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |